Development of Ti-Al intermetallic compounds porous material with reactively synthesizing and its biological application

DOI

10.2991/mebe-15.2015.75How to use a DOI?

Keywords

Staphylococcus aureus ssp. anaerobius (S. aureus); Penicillin G; Targeted drug delivery; Bone; Ti-Al intermetallic compounds porous material.

Abstract

Bacterial infection is one of the most common problems after orthopedic implant surgery. If not prevented, bacterial infection can result in serious and life threatening conditions such as osteomyelitis. Thus, in order to reduce chances of such serious complication, patients are often subjected to antibiotic drug therapy for 6-8 weeks after initial surgery. The antibiotics are systemically delivered either intravenously, intramuscularly or topically. Systemic antibiotic delivery entails certain drawbacks such as systemic toxicity and limited bioavailability. Further, in order for the drug to be effective at the site of implantation, high doses are required, which can result in undesired side effects in patients. Thus, local antibiotic therapy is the preferred way of administering drugs. To that end, we have developed Ti-Al intermetallic compounds porous material for local delivery of antibiotics off-implant at the site of implantation. The Ti-Al intermetallic compounds porous materials were fabricated with reactively synthesizing. The fabrication strategies allow us to precisely control the dimension of aperture, thus enabling us to load different amounts of drugs and control the release rates. In this work we have fabricated Ti-Al intermetallic compounds porous material with 40 ~ 200 nm and 2 ~ 5 m apertures. We have loaded these tubes with 180, 360 and 540 g of penicillin G. The penicillin G release kinetics from the apertures and its effect on Staphylococcus aureus ssp. anaerobius (S. aureus) adhesion were investigated. Further, an osteosarcoma cell line called MG-63 was cultured on penicillin G-loaded aperture to evaluate the effect of Ti-Al intermetallic compounds porous material on cell functionality. Our results indicate that we can effectively fill the apertures with the drug and the drug eluting apertures significantly reduced bacterial adhesion on the surface. Also, there is enhanced MG-63 differentiation on apertures filled with penicillin G.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xilin Xiao
AU  - Lifu Liao
AU  - Changming Nie
AU  - Xin Zhou
AU  - Bo He
AU  - Chang’ai Deng
PY  - 2015/04
DA  - 2015/04
TI  - Development of Ti-Al intermetallic compounds porous material with reactively synthesizing and its biological application
BT  - Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering
PB  - Atlantis Press
SP  - 316
EP  - 319
SN  - 2352-5401
UR  - https://doi.org/10.2991/mebe-15.2015.75
DO  - 10.2991/mebe-15.2015.75
ID  - Xiao2015/04
ER  -