Manganese-Induced Effects on Calcium Homeostasis of the Neurons in Hyline Cocks

DOI

10.2991/mebe-15.2015.34How to use a DOI?

Keywords

Manganese; Calcium Homeostasis; Neurons; Cocks

Abstract

Manganese (Mn) is known to be essential for maintaining the proper function and regulation of many biochemical. To investigate the toxicity of Mn on bird brains, 50-day-old cocks were fed either a commercial diet or a Mn-supplemented diet. the following were determined: Mn concentration, Ca2+ concentration, the expression of Calmodulin (CaM) and Calcineurin (CaN) gene. Exposure to Mn significantly lowered expression of CaM and CaN gene. However, Mn was accumulated in brain and the Ca2+ concentration was increased. These findings suggested that Mn exposure resulted in the damage of cock cerebral tissue by altering calcium homeostasis, which are possible underlying neurotoxicity mechanisms.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiaofei Liu
AU  - Lirong Jing
AU  - Lv Xue
AU  - Yongqiang Ma
AU  - Huanan Guan
AU  - Wang Wei
PY  - 2015/04
DA  - 2015/04
TI  - Manganese-Induced Effects on Calcium Homeostasis of the Neurons in Hyline Cocks
BT  - Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering
PB  - Atlantis Press
SP  - 139
EP  - 142
SN  - 2352-5401
UR  - https://doi.org/10.2991/mebe-15.2015.34
DO  - 10.2991/mebe-15.2015.34
ID  - Liu2015/04
ER  -