Lipase Catalyzed Naproxen Methyl Ester Enantioselective Hydrolysis in Ionic Liquids

DOI

10.2991/mcei-16.2016.4How to use a DOI?

Keywords

Lipase; Enantioselective hydrolysis; Naproxen; Ionic liquids; Biphasic system

Abstract

A series of dialkylimidazolium ionic liquids with various anions including hexafluorophosphate alkane sulfonate and tetrafluoroborates were studied in the lipase-catalyzed enantioselective hydrolysis. Lipase activity,stability and enantioselectivity were determined by both of alkane and anions. In the best aqueous- C4mimPF6 biphasic system lipase resolution of Naproxen proceed with much effective. It was observed that the activity of lipase in aqueous- C4mimPF6 system was comparable with that in aqueous-organic system, but the enantiomeric ratio of Lipase-catalysis hydrolysis in aqueous - C4mimPF6 biphasic system (E>300) was much higher than that in aqueous -organic biphasic system (E 90).

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Shengbo Gao
AU  - Quanhui Li
AU  - Tingting Yao
AU  - Zhengyang Wang
AU  - Luoyun Zheng
AU  - Jiaying Xin
PY  - 2016/12
DA  - 2016/12
TI  - Lipase Catalyzed Naproxen Methyl Ester Enantioselective Hydrolysis in Ionic Liquids
BT  - Proceedings of the 2016 6th International Conference on Mechatronics, Computer and Education Informationization (MCEI 2016)
PB  - Atlantis Press
SP  - 14
EP  - 17
SN  - 1951-6851
UR  - https://doi.org/10.2991/mcei-16.2016.4
DO  - 10.2991/mcei-16.2016.4
ID  - Gao2016/12
ER  -