Biological evaluation of PRGD/PDLLA for nerve regeneration scaffold

DOI

10.2991/mce-14.2014.140How to use a DOI?

Keywords

Schwann cells; PRGD/PDLLA; Implantation; Inflammatory factors; Biocompatibility

Abstract

Objective: To develop a novel scaffold for nerve regeneration and explore its biocompatibility through culturing Schwann cells (SCs) on it an in vivo implantation. Methods: A novel scaffold of PDLLA with arginine–glycine–aspartic acid (RGD) peptide (PRGD/PDLLA) was synthesized.The proliferation of Schwann cells (SCs) concultured with PDLLA films (control group) and PRGD/PDLLA films were evaluated by MTT assay and scanning electron microscope observation. Then, histological assessment and ELISA testing on inflammatory-related cytokines TGF- 1 were performed. Results: compared with PDLLA, PRGD/PDLLA films possesses better hydrophilicity biocompatibility, degradation property and less inflammatory reaction. Conclusion: The present study indicated that PRGD/PDLLA scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.

Copyright

© 2014, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zhu Zhang
AU  - Jiling Yi
AU  - Xiaopei Wu
AU  - Qiongjiao Yan
AU  - Yixia Yin
AU  - Shipu Li
PY  - 2014/03
DA  - 2014/03
TI  - Biological evaluation of PRGD/PDLLA for nerve regeneration scaffold
BT  - Proceedings of the 2014 International Conference on Mechatronics, Control and Electronic Engineering
PB  - Atlantis Press
SP  - 629
EP  - 632
SN  - 1951-6851
UR  - https://doi.org/10.2991/mce-14.2014.140
DO  - 10.2991/mce-14.2014.140
ID  - Zhang2014/03
ER  -