Effects of Pre-inhalation of Salbutamol on Cough Reflex Induced by Sufentanil

DOI

10.2991/mcae-16.2016.56How to use a DOI?

Keywords

salbutamol; sufentanil; cough; pre-inhalation

Abstract

Purposes: This study was designed to evaluate the effect of pre-inhalation of salbutamol aerosol(200?g) and injection speed on sufentanil-induced cough. Methods: 160 patients aged 25-62yr, ASA I-?, scheduled for various elective surgical procedures under general anesthesia were randomly allocated into four groups of 40 each. Group ?, ? served as control received saline aerosol, and Group I, ? received a pre-inhalation of one metered aerosol puff of salbutamol(200?g) 10min prior to intravenous injection of sufentanil. Sufentanil 0.5?g/kg was administered within 3s in GroupI, ?, or over 30s in Group ?, ?. The concentration of sufentanil was 10?g/ml. The incidences and severity of cough that occurred within 1 min after the injection of sufentanil were recorded, the HR and SBP at pre-anesthetic(T1), 5 minutes after inhalation(T2) , and 1 minute after injecting sufentanil (T3) were also recorded. Results: The incidence of cough in GroupI, ?(10%,12.5%) were less than Group ?(37.5%) (p<0.05); The incidence of cough in Group ?(2.5%) was significantly lower Group ? (p<0.01). The highest non-invasive blood (NIBP) and heart rate (HR) were at T3 timepoint in Group ?(p<0.05). Conclusions: The pre-inhalation of salbutamol(200?g) combined with a prolonged injection time significantly reduced the incidence of sufentanil-induced.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Jie Li
AU  - Kai Li
PY  - 2016/07
DA  - 2016/07
TI  - Effects of Pre-inhalation of Salbutamol on Cough Reflex Induced by Sufentanil
BT  - Proceedings of the 2016 International Conference on Mechatronics, Control and Automation Engineering
PB  - Atlantis Press
SP  - 237
EP  - 239
SN  - 2352-5401
UR  - https://doi.org/10.2991/mcae-16.2016.56
DO  - 10.2991/mcae-16.2016.56
ID  - Li2016/07
ER  -