Proceedings of the 4th International Conference on Key Enabling Technologies (KEYTECH 2024)

<Previous Article In Volume
Next Article In Volume>

Encapsulation of Paclitaxel in Single-Walled Carbon Nanotubes (CNT) for Targeted Drug Delivery of Cancer: A Simulation Study

Authors
Muhammad Jawad Shafique1, *, Syed Faraz Jawed2, Mariam Raziq1, Sidra Abid Syed1, Syed Hasan Sarwar3, Muhammad Usman Baig1
1Biomedical Engineering Department, Sir Syed University of Engineering and Technology, Karachi, Pakistan
2Biomedical Engineering Department, NED University of Engineering and Technology, Karachi, Pakistan
3Biomedical Engineering Department, Ziauddin University, Karachi, Pakistan
*Corresponding author. Email: mjshafique@ssuet.edu.pk
Corresponding Author
Muhammad Jawad Shafique
Available Online 24 December 2024.
DOI
10.2991/978-94-6463-602-4_5How to use a DOI?
Keywords
Biomaterials; Carbon nanotube; Drug delivery system; Encapsulation; Molecular Simulation; Paclitaxel
Abstract

The application of nanotechnology is significant in that it is exploited substantially, such as employing CNTs for targeted delivery of anti-cancer drugs. Through molecular dynamics (MD) simulations with Materials Studio Software, the anti-cancerous carbon nanotube drug delivery system for supporting SWCNTs has been studied. Secondly, Paclitaxel is an anticancer drug that inhibits the DNA synthesis of active cells – cancer cells; subsequently, the drug can reduce the tumour size. One promising strategy for achieving controlled drug release involves placing paclitaxel drugs inside SWCNT. This has been studied in the current article. The drug moved down the end to about the tube’s midline within just 50 ps. Essential properties, such as energy, temperature, etc., have also been identified. The study thus reports a quick encapsulation behaviour of this drug within the SWCNT.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

<Previous Article In Volume
Next Article In Volume>
Volume Title
Proceedings of the 4th International Conference on Key Enabling Technologies (KEYTECH 2024)
Series
Atlantis Highlights in Engineering
Publication Date
24 December 2024
ISBN
978-94-6463-602-4
ISSN
2589-4943
DOI
10.2991/978-94-6463-602-4_5How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Muhammad Jawad Shafique
AU  - Syed Faraz Jawed
AU  - Mariam Raziq
AU  - Sidra Abid Syed
AU  - Syed Hasan Sarwar
AU  - Muhammad Usman Baig
PY  - 2024
DA  - 2024/12/24
TI  - Encapsulation of Paclitaxel in Single-Walled Carbon Nanotubes (CNT) for Targeted Drug Delivery of Cancer: A Simulation Study
BT  - Proceedings of the 4th International Conference on Key Enabling Technologies (KEYTECH 2024)
PB  - Atlantis Press
SP  - 34
EP  - 40
SN  - 2589-4943
UR  - https://doi.org/10.2991/978-94-6463-602-4_5
DO  - 10.2991/978-94-6463-602-4_5
ID  - Shafique2024
ER  -