Nano-newton scale hydrodynamic force measurement through CFD modeling of spinning disc

DOI

10.2991/978-94-6463-602-4_15How to use a DOI?

Abstract

Understanding the molecular scale and mesoscale behavior of cell adhesion proteins is highly useful in solving real-world tissue engineering problems. Therefore, the present study attempts to analyze the mesoscale behavior of adhesions through numerical simulation. The computational fluid dynamics CFD simulation is performed to determine the hydrodynamic force on the mesoscale using spherical particles that represent the cells, attached to a spinning disc through the force of adhesion. The spinning disc is rotating in a TBS buffer with 1 mM of Ca2+ with almost similar physical properties to water. To determine the Nano-newton scale force eight spherical particles were attached to the spinning disc along the radial direction. The hydrodynamic force acts on the mesoscale spherical particles were determined at 3000 and 4000 rpm. As the size of the particles is negligible as compared to the size of the spinning disc and the Reynolds number is quite low, therefore, flow is considered as laminar. Numerical simulation revealed that hydrodynamic force acting on the spherical particles varies linearly along the radial direction. Moreover, fluid velocity over the disc surface also varies linearly in the radial direction. It is also estimated that drag force acting the particles is 10 times higher as compared to lift force and force acting in radial direction.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Intizar Ali
AU  - Zarah Walsh Korb
AU  - Tanweer Hussain
AU  - Abi Waqas
AU  - Inam Ul Ahad
PY  - 2024
DA  - 2024/12/24
TI  - Nano-newton scale hydrodynamic force measurement through CFD modeling of spinning disc
BT  - Proceedings of the 4th International Conference on Key Enabling Technologies (KEYTECH 2024)
PB  - Atlantis Press
SP  - 103
EP  - 109
SN  - 2589-4943
UR  - https://doi.org/10.2991/978-94-6463-602-4_15
DO  - 10.2991/978-94-6463-602-4_15
ID  - Ali2024
ER  -