Screening of Three Species of Pasak Bumi (Bitter Charm) for Potential Toxicities as Active Drugs

DOI

10.2991/absr.k.210408.055How to use a DOI?

Keywords

Pasak Bumi, Potential Toxicities, Active Drug, Traditional Medicines

Abstract

The utilization of traditional medicine or herbal medicine in a community is something inheritance, and it is inseparable from human lives. Support of scientific statements is necessary for comprehensive utilization. Pasak Bumi (Bitter Charm) is one of the raw material sources for traditional medicines that can be packaged inactive drugs that are benefits have been widely felt. This study is intended for preliminary screening of 3 types of Bitter Charm, including Yellow Bitter Charm (Eurycoma longifolia), Red (Rennellia elliptica) and Black (Trivalvaria macrophylla) as active drug ingredients through toxicity tests. Toxicity testing was carried out on all parts of Bitter Charm (roots, stems and leaves), which were first extracted (by ethanol, ethyl acetate and water solvent) using the BSLA (brine shrimp lethality assay) method through four test solutions with different concentrations, i.e. 10, 100, 500 and 1000 ppm. Results of toxicity testing of Bitter Charm extracts showed that based on the value of 50% Lethal Concentration (LC50), all Bitter Charm extracts showed that those extract had toxic potential (LC50 <1000 ppm). The lowest toxicity value on Yellow Bitter Charm extract was found in leaves with ethyl acetate solvent (132.08 ppm), the lowest toxicity value in Red Bitter Charm extract was in leaves with water solvent (287.59 ppm), and the lowest toxicity value in Black Bitter Charm extract was found in stems with water solvents (58.94 ppm). However, this recent study stated that all parts of the Bitter Charm of 3 different species contained high toxicity. As evidenced by the smaller LC50 value, the smaller LC50 value means the active compound has more toxic. Increasingly of toxicity inactive compound means potential highly as an anti-cancer, antibacterial, and antifungal.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Supartini
AU  - Rizki Maharani
AU  - Totok Kartono Waluyo
PY  - 2021
DA  - 2021/04/10
TI  - Screening of Three Species of Pasak Bumi (Bitter Charm) for Potential Toxicities as Active Drugs
BT  - Proceedings of the Joint Symposium on Tropical Studies (JSTS-19)
PB  - Atlantis Press
SP  - 323
EP  - 328
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.210408.055
DO  - 10.2991/absr.k.210408.055
ID  - 2021
ER  -