Synthesis and Antitumor Activity of Novel 4,5-Disubstituted Triazole Derivatives

DOI

10.2991/itms-15.2015.269How to use a DOI?

Keywords

triazole; antitumor

Abstract

A series of 4,5-disubstituted triazole derivatives(5a--5d) were prepared starting from substituted aniline via aminolysis reaction, cyclisation, alkylation, deprotection. All the synthesized compounds were screened for cytotoxic activity against three human cancer cell lines such as MCF-7, Hela and A549. Compound 5b was found to be most active with IC50 values 7.20 M and 7.31 M against MCF-7 and A549, respectively.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - W.Y. Yuan
AU  - Y.N. Weng
AU  - N.N. Liu
AU  - Q.P. Wu
PY  - 2015/11
DA  - 2015/11
TI  - Synthesis and Antitumor Activity of Novel 4,5-Disubstituted Triazole Derivatives
BT  - Proceedings of the 2015 International Conference on Industrial Technology and Management Science
PB  - Atlantis Press
SP  - 1105
EP  - 1106
SN  - 2352-538X
UR  - https://doi.org/10.2991/itms-15.2015.269
DO  - 10.2991/itms-15.2015.269
ID  - Yuan2015/11
ER  -