Effects of Excess or Insufficient Energy on Immune System of Mice

DOI

10.2991/978-2-494069-31-2_61How to use a DOI?

Keywords

diet restriction; obesity; excess energy; immunity

Abstract

Nowadays, people have found that excessive or too little energy intake has a great impact on the immune system. Excess energy may lead to weakened immunity, making obese patients more prone to chronic inflammation and tumors. However, the specific molecular mechanism of excess energy acting on the immune system is still not clear. There are also differences in the total impact of too little energy on the human immune system. Therefore, by summing up various opinions and drawing on the research results of a large number of papers, this paper systematically summarizes the impact of energy on the immune system in order to let others have a more comprehensive and profound understanding of the progress in related fields. Through the research, the paper finds that energy deficiency can affect the properties of immune organs and especially reduce the weight of the spleen. Obesity and splenomegaly are closely related and have a certain causal relationship. Obese patients can significantly reduce or keep the peripheral blood T cells unchanged, and their impact on immunity is controversial. Dieting has a positive effect on obese patients and a negative effect on normal people. On the one hand, obesity can promote the activation of macrophages and Th1 cells and strengthen the inflammatory response. On the other hand, adipose tissue itself can secrete cytokines such as leptin to cause chronic inflammation. Obesity can inhibit tumor immunity by affecting the tumor microenvironment, leading to tumor formation.

Copyright

© 2022 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Yunfei Ji
PY  - 2022
DA  - 2022/12/29
TI  - Effects of Excess or Insufficient Energy on Immune System of Mice
BT  - Proceedings of the 2022 6th International Seminar on Education, Management and Social Sciences (ISEMSS 2022)
PB  - Atlantis Press
SP  - 489
EP  - 495
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-494069-31-2_61
DO  - 10.2991/978-2-494069-31-2_61
ID  - Ji2022
ER  -