How Lysosomes Protect Themselves from Corrosion in High Acid Environments

DOI

10.2991/978-2-494069-31-2_184How to use a DOI?

Keywords

Glycosylation; lysosome; mitochondria; Apo D

Abstract

Lysosomes are important metabolic sensors for many substances’ cell growth and metabolic processes are also the center of explanation of substances in cells. Mitochondria, likewise, serve the main metabolic center of the cell. These two things interact with each other to regulate cellular metabolism and are inextricably linked to neurodegenerative diseases and lysosomal storage disorders. With current knowledge and investigations, we know that the membrane of lysosomes is very susceptible to damage. They can be affected by oxidative stress and similar environmental factors, so they need to protect themselves from corrosion in a highly acidic environment by some specific means. Judging from the current research, there is still a blank in this field. The current study proposes the use of glycosylation to protect lysosomes, but the disadvantage of this method is that it has a certain instability, and under certain circumstances, lysosomes will still be corroded by acid. Through experiment, this paper discusses how lipocalin apolipoprotein D (ApoD) is protected in an acidic environment of the cell membrane of the lysosome, and through research and investigation, this study found that a protein called lipocalin apolipoprotein D (ApoD) that can effectively prevent lysosomes from being corroded by acidity.

Copyright

© 2022 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Jinglin Lu
PY  - 2022
DA  - 2022/12/29
TI  - How Lysosomes Protect Themselves from Corrosion in High Acid Environments
BT  - Proceedings of the 2022 6th International Seminar on Education, Management and Social Sciences (ISEMSS 2022)
PB  - Atlantis Press
SP  - 1563
EP  - 1569
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-494069-31-2_184
DO  - 10.2991/978-2-494069-31-2_184
ID  - Lu2022
ER  -