CAR-NK Cell Therapy: A Promising Alternative to CAR-T Cell Therapy

DOI

10.2991/978-2-494069-31-2_48How to use a DOI?

Keywords

cancer; immunology; chimeric antigen receptor; NK cells

Abstract

Cancer is one of the deadliest diseases and has long been a leading cause of death. Although the newly introduced chimeric antigen receptors-engineered T cell (CAR-T cell) therapy has been an efficient method to kill cancer cells and inhibit metastasis, its high cytotoxicity, long time to develop, and high cost due to its patient-specific nature suggest that a new treatment is needed. In recent years, researchers have been paying increasing interest in implementing CAR on natural killer cells (NK cells), making them CAR-NK cells similarly to making CAR-T cells. This paper focuses on the process of CAR-NK cell therapy and the extent to which it excels over CAR-T therapy. From several published research and data, it can be concluded that CAR-NK therapy cell is a promising alternative to CAR-T cell therapy as it offers various key advantages including better safety, production convenience, and tumor targeting efficacy. However, challenges such as low cell persistence and transduction efficiency still need to be resolved by further studies and improvements.

Copyright

© 2022 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Jinqiao Hu
PY  - 2022
DA  - 2022/12/29
TI  - CAR-NK Cell Therapy: A Promising Alternative to CAR-T Cell Therapy
BT  - Proceedings of the 2022 6th International Seminar on Education, Management and Social Sciences (ISEMSS 2022)
PB  - Atlantis Press
SP  - 372
EP  - 381
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-494069-31-2_48
DO  - 10.2991/978-2-494069-31-2_48
ID  - Hu2022
ER  -