Supramolecular Compounds of β-cyclodextrins as a Material for the Pharmaceutical Industry

DOI

10.2991/isees-19.2019.37How to use a DOI?

Keywords

cyclodextrin; amino acids; inclusion complexes; complexes of amino acids with rare-earth elements.

Abstract

The binary systems Eu(L)3(ClO4)3∙2H2O and ternary systems EuL3(CD)3∙2H2O were synthesized. The structural features of the systems were analyzed. The composition and structure of the synthesized complex compounds were studied by NMR spectroscopy, IR spectroscopy, X-ray phase analysis, thermal analysis, and luminescence analysis. It was revealed that during formation of the ternary system, the amino acid enters the cyclodextrin cavity and is preserved by hydrogen bonds; coordination with Eu3 + is due to the carboxyl group (COO-), which is outside the cyclodextrin cavity. It was assumed that the spatial structure of the ternary system includes metal, amino acid, and β – cyclodextrin, where the ion of europium is used as a metal. It is used to track drug transportation in the biological systems.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - E.L. Isaeva
AU  - Khasaeva S.S. Khasaeva
AU  - E.R. Aslambekova
AU  - V.T. Panyushkin
PY  - 2019/08
DA  - 2019/08
TI  - Supramolecular Compounds of β-cyclodextrins as a Material for the Pharmaceutical Industry
BT  - Proceedings of the International Symposium "Engineering and Earth Sciences: Applied and Fundamental Research" dedicated to the 85th anniversary of H.I. Ibragimov (ISEES 2019)
PB  - Atlantis Press
SP  - 638
EP  - 645
SN  - 2590-3217
UR  - https://doi.org/10.2991/isees-19.2019.37
DO  - 10.2991/isees-19.2019.37
ID  - Isaeva2019/08
ER  -