Preparation and Dissolution of Solid Dispersions of Sanguis Draconis

DOI

10.2991/ifmca-16.2017.141How to use a DOI?

Keywords

sanguis draconis, solid dispersions, dissolubility, polyethylene glycol, polyvinyl pyrrolidone

Abstract

Sanguis draconis is a precious traditional Chinese medicine, but it is not soluble in water, and it is difficult to use in type of injection. Sanguis draconis has a low bioavailability, because the coarse particles of draconis can be absorbed very little. In present research, solid dispersions of sanguis draconis were prepared using solvent method and melting methods with PEG-6000 and PVPK30 as carriers. The dissolubility in vitro was determined by UV method. Results showed that higher carrier ratio led to faster drug dissolution. The dissolubility of solid dispersions with PVPK30 was faster than that with PEG-6000. The solid dispersions of sanguis draconis can improve its dissolution obviously, which promotes the absorption and bioavailability of this medicine.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Chang Min Xing
AU  - Xue Ming Wang
AU  - Kuan Cao
AU  - Hui Chao Liu
AU  - Yong Liu
AU  - Nan Li
PY  - 2017/03
DA  - 2017/03
TI  - Preparation and Dissolution of Solid Dispersions of Sanguis Draconis
BT  - Proceedings of the 2016 International Forum on Mechanical, Control and Automation (IFMCA 2016)
PB  - Atlantis Press
SP  - 900
EP  - 903
SN  - 2352-5401
UR  - https://doi.org/10.2991/ifmca-16.2017.141
DO  - 10.2991/ifmca-16.2017.141
ID  - Xing2017/03
ER  -