Design and Fabrication of Vascular Network for Muscle Tissue Engineering

DOI

10.2991/ifeesd-16.2016.112How to use a DOI?

Keywords

Vascular network, Gelatin hydrogel, Muscle tissue engineering

Abstract

Function loss of large skeletal muscle is an urgent problem in the clinic. Although the artificial microfluidic network encapsulated in thick tissue-engineered constructs has a great promise, it is still difficult to develop an efficient microfluidic design to fit the requirements of the bionic vascular network for tissue engineering application. In this study, a seriers of biomimetic principles was outlined and a vascular network for muscle tissue engineering was designed following these principles. CFD analysis indicated that the velocity error of fabricated model was controlled within 10% in the different pressures, the velocity curve of designed model and fabricated model are better matched when the inlet pressure is 6 mmHg. Therefore, the future work will focus on the in vitro tests with this inlet parameter to verificate and optimize the vascular networks and validating their ability to support myoblast for clinical use.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Guirong Dong
AU  - Qin Lian
AU  - Laixia Yang
AU  - Wei Mao
AU  - Shiyang Liu
AU  - Chao Xu
PY  - 2016/05
DA  - 2016/05
TI  - Design and Fabrication of Vascular Network for Muscle Tissue Engineering
BT  - Proceedings of the 2016 International Forum on Energy, Environment and Sustainable Development
PB  - Atlantis Press
SP  - 613
EP  - 621
SN  - 2352-5401
UR  - https://doi.org/10.2991/ifeesd-16.2016.112
DO  - 10.2991/ifeesd-16.2016.112
ID  - Dong2016/05
ER  -