Vitamin-D and Dexamethasone Stimulation of Estrogen Receptor-?' and Androgen Receptor in Osteoblasts of Aggressive Periodontitis

DOI

10.2991/idsm-17.2018.38How to use a DOI?

Keywords

aggressive periodontitis, vitamin D and dexamethasone, osteoblasts, estrogen re-ceptor α, androgen receptor

Abstract

The objective of this study is to investigate the expression of estrogen receptor α and androgen receptor in osteoblasts derived from patients with aggressive perio-dontitis following stimulation using vitamin D and dexamethasone. Sample pieces of alveolar bone were collected from patients with aggressive periodontitis (PA) and from non-periodontitis subjects (NP), for both of which the patient's consent had been obtained. Osteoblasts were isolated from bone fragments by the explant method, stimulated with vitamin D and dexamethasone, and then examined for the expression of ERα and AR using immunohistochemical staining. Increased expression of ERα-PA (RR: 1.1; CC: 0.61 to 1.99; p = 752) and ARC-PA (RR: 1.62; CI: 0.87-3, p = 0.13) determined that vitamin D and dexamethasone stimu-lated osteoblasts showed increased receptor expression than those from healthy controls (non-periodontitis). Stimulation using vitamin D and dexamethasone in-creased the expression of ERα, and AR in the osteoblasts.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Dahlia Herawati
PY  - 2018/05
DA  - 2018/05
TI  - Vitamin-D and Dexamethasone Stimulation of Estrogen Receptor-?' and Androgen Receptor in Osteoblasts of Aggressive Periodontitis
BT  - Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SP  - 280
EP  - 287
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.38
DO  - 10.2991/idsm-17.2018.38
ID  - Herawati2018/05
ER  -