Ectodermal Dysplasia

DOI

10.2991/idsm-17.2018.31How to use a DOI?

Keywords

ectodermal dysplasia, mutation, EDA gene, EDAR gene, EDARADD gene

Abstract

Primary defects in the development of two or more ectoderm-derived tissues are shared by a rare heterogeneous group of inherited disorders called ectodermal dysplasia (ED) syndrome. The affected tissues are primarily the hair, skin, teeth, sweat glands, and nails. The most common phenotype of ED is hypohidrotic ED (HED), which is characterized by hypohidrosis/anhidrosis, hypotrichosis, and hy-podontia/anodontia. Other clinical features of HED include frontal bossing with prominent supraorbital ridges, nasal bridge depression, and protuberant lips. There are three subtypes of HED: autosomal recessive, autosomal dominant, and X-linked. Mutations to four genes (EDA, EDAR, EDARADD, and WNT10A) are re-sponsible for most cases of ED. Besides gene mutations, epigenetics also influ-ences gene expression and activity in ED syndrome. DNA methylation and his-tone modification are vital to the epigenetic regulation of the development of fe-male carriers of the X-linked subtype of HED.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Vassa Khema Katthika
AU  - Elza Ibrahim Auerkari
PY  - 2018/05
DA  - 2018/05
TI  - Ectodermal Dysplasia
BT  - Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SP  - 230
EP  - 238
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.31
DO  - 10.2991/idsm-17.2018.31
ID  - Katthika2018/05
ER  -