Proceedings of the 2nd International Conference on Science, Technology, and Modern Society (ICSTMS 2020)

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In Vitro Inhibition Against Angiotensin Converting Enzyme by Sonchus arvensis Water Extract and Fractions as Antihypertension

Authors
Trivadila, Lufthiah Hasnah Iramani, Novriyandi Hanif, Sekar Ilma Tiarani, Min Rahminiwati, Dyah Iswantini
Corresponding Author
Dyah Iswantini
Available Online 11 September 2021.
DOI
10.2991/assehr.k.210909.100How to use a DOI?
Keywords
angiotensin converting enzyme, antihypertension, inhibitor, Sonchus arvensis, tempuyung
Abstract

Hypertension is a condition in which a person has an elevating in blood pressure above normal, resulting in an increasing in morbidity and mortality. One mechanism of treating hypertension is by inhibiting the formation of angiotensin converting enzyme (ACE). Sonchus arvensis, known as tempuyung, widely used in treating various diseases, such as diuretic, anti-inflammatory, and antihypertensive The purpose of this study was to test the in vitro inhibition of single extracts, namely polar layer BuOH, semipolar layer CH2Cl2, and nonpolar layer n-hexane of the tempuyung leaves toward ACE activity and compare their activity with a synthetic drugs (captopril). The sample were percolated in water, partitioned, and gave three layers. The polar BuOH layer exhibited the highest inhibition percentage of 45%, followed by CH2Cl2 layer with 42%, and n-hexane layer by 39%, while the captopril showed inhibition of 48%. The BuOH layer is potential to be developed for antihypertensive drug through the ACE inhibition mechanism, as indicated by the close to captopril inhibitory capacity in vitro.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2nd International Conference on Science, Technology, and Modern Society (ICSTMS 2020)
Series
Advances in Social Science, Education and Humanities Research
Publication Date
11 September 2021
ISBN
978-94-6239-426-1
ISSN
2352-5398
DOI
10.2991/assehr.k.210909.100How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Trivadila
AU  - Lufthiah Hasnah Iramani
AU  - Novriyandi Hanif
AU  - Sekar Ilma Tiarani
AU  - Min Rahminiwati
AU  - Dyah Iswantini
PY  - 2021
DA  - 2021/09/11
TI  - In Vitro Inhibition Against Angiotensin Converting Enzyme by Sonchus arvensis Water Extract and Fractions as Antihypertension
BT  - Proceedings of the 2nd International Conference on Science, Technology, and Modern Society (ICSTMS 2020)
PB  - Atlantis Press
SP  - 470
EP  - 475
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.210909.100
DO  - 10.2991/assehr.k.210909.100
ID  - 2021
ER  -