PCSK1 Variants and Obesity: Relationship in Different Population
- DOI
- 10.2991/assehr.k.220110.187How to use a DOI?
- Keywords
- Obesity; PCSK1 variant; Disease; Population
- Abstract
With the development of economy, obesity is now a common chronic disease which is becoming increasingly common all over the world. Up to 39% of adults worldwide are overweight. While 20 percent of children and adolescents, globally, are obese in 2020. Obesity can be affected by genetic factors, and PCSK1 was confirmed to be related to single gene obesity. PCSK1 encodes PC1/3 protein, and it is expressed not only in the peripheral nervous system and central nervous system but also in the endocrine and neuroendocrine organs. It regulates the production of several types of anorexia hormones and appetite-stimulating hormones, therefore, regulating food intake and body weight. It also plays a role in the endocrine system in regulating appetite, glucose homeostasis and nutrient assimilation. Thus, to figure out the effect of PCSK1 mutation on different humans’ population and relationship between PCSK1 variants and obesity, this paper used the method of gathering studies of other scholars and analyzed the structure and function of PCSK1, as well as obesity degree of PCSK1 variation in different populations. Finally, it is concluded that common variants of PCSK1, such as rs6232 and rs6234/6235, were shown to be significantly associated with obesity risk, and these risks are strongly modulated by age and ethnicity. The results showed that PCSK1 had a greater effect on obesity in the young population, and rs6232 was associated with obesity in the white European population while rs6235 and rare mutations were associated with obesity in the Asian African population.
- Copyright
- © 2022 The Authors. Published by Atlantis Press SARL.
- Open Access
- This is an open access article under the CC BY-NC license.
Cite this article
TY - CONF AU - Xiangtong Sha AU - Yueqiang Wang PY - 2022 DA - 2022/01/28 TI - PCSK1 Variants and Obesity: Relationship in Different Population BT - Proceedings of the 2021 International Conference on Public Art and Human Development ( ICPAHD 2021) PB - Atlantis Press SP - 990 EP - 993 SN - 2352-5398 UR - https://doi.org/10.2991/assehr.k.220110.187 DO - 10.2991/assehr.k.220110.187 ID - Sha2022 ER -