Review on Utilizing Grp78 on Endometrial Cancer Therapy

DOI

10.2991/assehr.k.220110.115How to use a DOI?

Keywords

Endometrial cancer; Grp78; ER stress; Chemoresistance; Radioresistance

Abstract

The significance of Grp78 gene expression in cancer has been confirmed for many years, yet the feasibility of applying Grp78 targeting treatment in endometrial cancer remains questioned. By reviewing past research that specifies the therapeutic value of Grp78, this article concludes that Grp78 has the potential of acting as a prognostic factor, and target for promoting chemosensitivity and radiosensitivity in endometrial cancer treatment. This article also includes the mechanism behind Grp78 expression-induced chemoresistance, which provides an alternative therapy for drug resistance. Despite various applications exist, huge risks come with manipulating ER stress-related genes, which requires further study.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Yunqi Bao
PY  - 2022
DA  - 2022/01/28
TI  - Review on Utilizing Grp78 on Endometrial Cancer Therapy
BT  - Proceedings of the 2021 International Conference on Public Art and Human Development ( ICPAHD 2021)
PB  - Atlantis Press
SP  - 597
EP  - 603
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220110.115
DO  - 10.2991/assehr.k.220110.115
ID  - Bao2022
ER  -