Factors That Cause and Affect Cancer Metastases, the Targeted Therapy and Potential Treatments

DOI

10.2991/assehr.k.220110.074How to use a DOI?

Keywords

Cancer metastases; Targeted Therapy; Malignant tumor; Circulating tumor cells; Biomechanics

Abstract

The metastases are a series of mechanisms for circulating malignant tumor cells to travel and occupy distant organs. This includes infiltrating distant tissue, evading immune defenses, adapting to supportive niches, surviving as latent tumor-initiating seeds, and eventually breaking out to replace the host tissue[1]. Metastases like bone metastases can rapidly decline the survival quality and strongly affect the treatment protocol of the cancer patients. The original treatment will be unapplicable when metastases occur, therefore researching and gaining a better understanding of metastatic cancers’ mechanisms is essential to cure or avoid cancer patients to endure tumor cell metastases. This review summarizes and develops based on the existing theories and hypotheses relevant to the intrinsic modification of cancer metastases. The promoting factors in the aggressive metastases had been characterized in the review aiming to provide a clear vision of potential and valuable research orientation regarding cancer metastases. Targeted therapy, immunotherapy, and potential treatment according to current studies will be summarized and depict. The paper finds that the knowledge of the process of cancer cell migration is now largely developed and several basic steps, such as invasion, survival, and colonization, have been established. A multifaceted and intact understanding of tumor cells and their subtle mechanism is expected in the following years.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Yiming Liao
PY  - 2022
DA  - 2022/01/28
TI  - Factors That Cause and Affect Cancer Metastases, the Targeted Therapy and Potential Treatments
BT  - Proceedings of the 2021 International Conference on Public Art and Human Development ( ICPAHD 2021)
PB  - Atlantis Press
SP  - 378
EP  - 381
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220110.074
DO  - 10.2991/assehr.k.220110.074
ID  - Liao2022
ER  -