Synthesis and Characterization of Hybrid Alginate/Cellulose Aerogels as Drug Delivery Carrier
- DOI
- 10.2991/aer.k.201229.039How to use a DOI?
- Keywords
- Sodium alginate (Na-Alg), supercritical CO2, aerogels, carboxymethyl cellulose (CMC), drug delivery carrier
- Abstract
Technology of material development on drug delivery system has expanded vastly nowadays. The potential of alginate and carboxymethyl cellulose (CMC) as drug delivery carrier is presented. The alginate and CMC was prepared as hybrid hydrogels via sol-gel method and dried by supercritical CO2 and at ambient conditions. Their mechanical strength was physically observed by their shrinkage percentage. Different concentration of alginate and CMC were synthesized to determine the effect of material variation composition on the physical and chemical characteristics. Physical and chemical properties of the hybrid aerogels were investigated by FTIR and TGA analysis. Results demonstrated that drying the hydrogels by supercritical CO2 produced alginate/CMC aerogels with smaller shrinkage percentage i.e. 12.5% in comparison to ambient drying that extremely shrank the hydrogel as high as 45.4%. for 3 wt% alginate/1 wt% CMC. This work suggests that the hybrid alginate/CMC aerogels dried by supercritical CO2 has a great potential to be applied as drug delivery carrier due to its mechanical strength and good thermal stability at high temperature.
- Copyright
- © 2020, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Siti Hajar Zolkepli AU - Ana Najwa Mustapa AU - Angel Martin Martinez AU - Maria Jose Cocero PY - 2020 DA - 2020/12/30 TI - Synthesis and Characterization of Hybrid Alginate/Cellulose Aerogels as Drug Delivery Carrier BT - Proceedings of the Third International Conference on Separation Technology 2020 (ICoST 2020) PB - Atlantis Press SP - 297 EP - 302 SN - 2352-5401 UR - https://doi.org/10.2991/aer.k.201229.039 DO - 10.2991/aer.k.201229.039 ID - Zolkepli2020 ER -