In Silico Analysis of NADH-Dependent Nitroreductase-Like Protein from Aspergillus parasiticus and Aspergillus caelatus

DOI

10.2991/978-94-6463-536-2_16How to use a DOI?

Keywords

Aspergillus; In Silico; Nitroreductase

Abstract

Nitroreductases have potential use in the bioremediation of nitroaromatic compounds and prodrug activation. Reports about this enzyme from bacteria are abundant; however, research on fungal nitroreductase is scarce. A. parasiticus nitroreductase (ApNtr) and A. caelatus nitroreductase (AcNtr), discovered via whole-genome sequencing, were studied. The physicochemical characteristics showed that ApNtr is cationic and AcNtr is anionic. Both proteins shared a common ancestor. The analysis of ApNtr and AcNtr structures shows that both proteins are comparable to nitroreductase from Saccharomyces cerevisiae and Lactococcus lactis, suggesting that these enzymes have similar functions, which are NADH-dependent nitroreductases.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Nurul Hamiemah Mohamad
AU  - Amaliawati Ahamad Latiffi
PY  - 2024
DA  - 2024/10/17
TI  - In Silico Analysis of NADH-Dependent Nitroreductase-Like Protein from Aspergillus parasiticus and Aspergillus caelatus
BT  - Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
PB  - Atlantis Press
SP  - 174
EP  - 182
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-536-2_16
DO  - 10.2991/978-94-6463-536-2_16
ID  - Mohamad2024
ER  -