Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)

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Metabolomics Reveals Deregulation of Lipid and Amino Acid Metabolisms in the Lungs of Rats Post-K. pneumoniae Infection

Authors
Nur Syauqina Najihah Mohd Rozali1, Muhd Hanis Md Idris1, 2, Mohd Ikhwan Ismail3, *, Nik Fatini Nik Azmin1, Mohd Izwan Mohamad Yusof1
1Faculty of Applied Science, Universiti Teknologi MARA (UiTM), Shah Alam, Malaysia
2Integrative Pharmacogenomics Institute (iPROMISE), Bandar Puncak Alam, Malaysia
3Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Malaysia
*Corresponding author. Email: ikhwanibnismail@gmail.com
Corresponding Author
Mohd Ikhwan Ismail
Available Online 17 October 2024.
DOI
10.2991/978-94-6463-536-2_20How to use a DOI?
Keywords
Klebsiella pneumonia; Metabolomics; Metabolisms
Abstract

The host’s metabolic response towards pathogenic infection was investigated using a Klebsiella pneumoniae infected rat model via metabolomics approaches. The lungs of rats serve as control and post-K. pnaumoniae infections were subjected to metabolomics analysis to assess the sensitivity of metabolomics in revealing metabolic changes and perturbations associated with the infection. 35 metabolites were significantly altered between the control and infected groups. Most of the detected metabolites were derived from lipid and amino acid metabolisms, suggesting that the host is under severe inflammation and oxidative stress even at post-K. pneumoniae infection. Our findings provide insight into the potential of metabolomics as a powerful tool for unravelling the pathogenesis of bacteremia.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
Series
Advances in Biological Sciences Research
Publication Date
17 October 2024
ISBN
978-94-6463-536-2
ISSN
2468-5747
DOI
10.2991/978-94-6463-536-2_20How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Nur Syauqina Najihah Mohd Rozali
AU  - Muhd Hanis Md Idris
AU  - Mohd Ikhwan Ismail
AU  - Nik Fatini Nik Azmin
AU  - Mohd Izwan Mohamad Yusof
PY  - 2024
DA  - 2024/10/17
TI  - Metabolomics Reveals Deregulation of Lipid and Amino Acid Metabolisms in the Lungs of Rats Post-K. pneumoniae Infection
BT  - Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
PB  - Atlantis Press
SP  - 232
EP  - 242
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-536-2_20
DO  - 10.2991/978-94-6463-536-2_20
ID  - Rozali2024
ER  -