Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)

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Optimization of Anti-Inflammatory Potential of Astaxanthin and Tocotrienols Cocktails in Lipopolysaccharide (LPS) Stimulating RAW 264.7 Macrophages

Authors
Maliya Azilah Mohammad Aini2, Muhamad Helmi Husaini Rusmidi1, Khairul Adzfa Radzun1, *, Nabiha Iran2, Faezah Pardi1, Asmida Ismail1, Wan Razarinah Wan Abdul Razak1, Sitti Rahma Abd Hafid2, *
1Faculty of Applied Sciences, Universiti Teknologi MARA, 40450, Selangor, Malaysia
2Malaysian Palm Oil Board, No.6 Persiaran Institusi, Bandar Baru Bangi, Kajang, Selangor D.E., Malaysia
*Corresponding author. Email: khairuladzfa@uitm.edu.my
*Corresponding author. Email: ctrahma@mpob.gov.my
Corresponding Authors
Khairul Adzfa Radzun, Sitti Rahma Abd Hafid
Available Online 17 October 2024.
DOI
10.2991/978-94-6463-536-2_5How to use a DOI?
Keywords
astaxanthin; tocotrienols; anti-inflammatory; RAW264.7 macrophages
Abstract

The rise in inflammatory diseases necessitates effective anti-inflammatory strategies. Astaxanthin and tocotrienols exhibit anti-inflammatory potential, with possible synergistic benefits. Combining multiple anti-inflammatory properties can provide a broad spectrum of protection. However, the effectiveness of such combinations varies depending on the synergistic effect and their proportions. This study established an optimal inflammation model using RAW264.7 cell-line, determining 15,000 cells/well and 10 ng/mL LPS as ideal conditions. Both compounds, individually and in combination, proved non-toxic and effectively reduced Nitrite Oxide (NO), a marker of inflammation. To enhance cost-effectiveness and maintain NO regulation, lower concentrations than previously reported (200 µg/mL and 100 µg/mL) are recommended for astaxanthin-tocotrienols formulations.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
Series
Advances in Biological Sciences Research
Publication Date
17 October 2024
ISBN
978-94-6463-536-2
ISSN
2468-5747
DOI
10.2991/978-94-6463-536-2_5How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Maliya Azilah Mohammad Aini
AU  - Muhamad Helmi Husaini Rusmidi
AU  - Khairul Adzfa Radzun
AU  - Nabiha Iran
AU  - Faezah Pardi
AU  - Asmida Ismail
AU  - Wan Razarinah Wan Abdul Razak
AU  - Sitti Rahma Abd Hafid
PY  - 2024
DA  - 2024/10/17
TI  - Optimization of Anti-Inflammatory Potential of Astaxanthin and Tocotrienols Cocktails in Lipopolysaccharide (LPS) Stimulating RAW 264.7 Macrophages
BT  - Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
PB  - Atlantis Press
SP  - 40
EP  - 57
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-536-2_5
DO  - 10.2991/978-94-6463-536-2_5
ID  - Aini2024
ER  -