Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)

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Toxicity Effects of Caffeine in ICR Mice Prior to Anti-malarial Study

Authors
Ahmad Zakwan Noriman1, Wan Nurhayati Wan Hanafi1, 2, Rusliza Basir3, Hani Kartini Agustar4, Mohd Ridzuan Mohd Abd Razak5, Wan Rozianoor Mohd Hassan1, 2, *
1School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia
2Genetic and Biochemistry, Research Nexus of UiTM (ReNeU), Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia
3Pharmacology Unit, Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia
4School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, UKM Bangi, Selangor, Malaysia
5Bioassay Unit, Herbal Medicine Research Center, Institute for Medical Research, National Institute of Health, 40170, Shah Alam, Selangor, Malaysia
*Corresponding author. Email: rozianoor@uitm.edu.my
Corresponding Author
Wan Rozianoor Mohd Hassan
Available Online 17 October 2024.
DOI
10.2991/978-94-6463-536-2_2How to use a DOI?
Keywords
Anti-malarial study; caffeine; ICR mice; toxicity effects
Abstract

Caffeine is a stimulant that increase alertness in the body. However, little is known on the toxicity effects of caffeine in ICR mice. This study aimed to identify the toxicity effects of caffeine in ICR mice for further anti-malarial investigation. Adult ICR mice were injected with caffeine (5, 10, 20 mg/kg) for four days via intraperitoneal injection (i.p.) and were monitored for 30 days. All doses exhibited no changes in body temperature, locomotor activity and urine colour when compared to control mice. Besides that, there were no signs of piloerection and lethargic whereas the mice body weight kept increasing in 30 days of monitoring. Therefore, the treatment of caffeine with 5, 10 and 20 mg/kg b.w. in ICR mice exhibited no toxicity signs and can be used for further anti-malarial study.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
Series
Advances in Biological Sciences Research
Publication Date
17 October 2024
ISBN
978-94-6463-536-2
ISSN
2468-5747
DOI
10.2991/978-94-6463-536-2_2How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Ahmad Zakwan Noriman
AU  - Wan Nurhayati Wan Hanafi
AU  - Rusliza Basir
AU  - Hani Kartini Agustar
AU  - Mohd Ridzuan Mohd Abd Razak
AU  - Wan Rozianoor Mohd Hassan
PY  - 2024
DA  - 2024/10/17
TI  - Toxicity Effects of Caffeine in ICR Mice Prior to Anti-malarial Study
BT  - Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
PB  - Atlantis Press
SP  - 3
EP  - 16
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-536-2_2
DO  - 10.2991/978-94-6463-536-2_2
ID  - Noriman2024
ER  -