Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)

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NMR Metabolomic Analysis on Sh-TINCR of MDA-MB-231 and HS578T Cell Lines: BHMT as a Potential Biomarker in TNBC Patients

Authors
Mohd Ikhwan Ismail1, Mohd Izwan Mohamad Yusof3, M. H. Ezanee Azlina2, M. H. Fazleen Haslinda1, *
1Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Malaysia
2UKM Medical Molecular Biology (UMBI), Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia
3Faculty of Applied Science, Universiti Teknologi MARA (UiTM), Shah Alam, Malaysia
*Corresponding author. Email: fazleen@uitm.edu.my
Corresponding Author
M. H. Fazleen Haslinda
Available Online 17 October 2024.
DOI
10.2991/978-94-6463-536-2_11How to use a DOI?
Keywords
BHMT; Metabolomics; TINCR; TNBC
Abstract

The poor outlook for triple-negative breast cancer (TNBC) is due in part to the absence of effective targeted treatments and the variability in clinical response to standard chemotherapy. Previously, we saw positive outcomes in reducing cancer cell survival on TINCR-knocked out cells and in this study TNBC cell lysates and culture medium were subjected to NMR metabolomic analyses. Spermine, Nicotinic acid, Cystathionine and Pyridoxal metabolites were found perturbed by the knocked-out process. This suggests that biosynthesis of cofactors metabolism took place and downstream analysis suggested BHMT protein could have potential for monitoring or prognostic biomarkers in TNBC cancer patients.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
Series
Advances in Biological Sciences Research
Publication Date
17 October 2024
ISBN
978-94-6463-536-2
ISSN
2468-5747
DOI
10.2991/978-94-6463-536-2_11How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Mohd Ikhwan Ismail
AU  - Mohd Izwan Mohamad Yusof
AU  - M. H. Ezanee Azlina
AU  - M. H. Fazleen Haslinda
PY  - 2024
DA  - 2024/10/17
TI  - NMR Metabolomic Analysis on Sh-TINCR of MDA-MB-231 and HS578T Cell Lines: BHMT as a Potential Biomarker in TNBC Patients
BT  - Proceedings of the International Conference on Science Technology and Social Sciences – Biology Track (ICONSTAS-BIO 2023)
PB  - Atlantis Press
SP  - 118
EP  - 129
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-536-2_11
DO  - 10.2991/978-94-6463-536-2_11
ID  - Ismail2024
ER  -