Mood Stabilizer Induced Steven Johnson Syndrome

A Case Report

DOI

10.2991/978-94-6463-616-1_6How to use a DOI?

Keywords

Mood stabilizers; Stevens-Johnson Syndrome

Abstract

Mood stabilizers are psychiatric medications used to help control mood swings commonly used to treat people with bipolar disorder. Mood stabilizers consist of several drugs, such as lithium, valproate, carbamazepine, clozapine, olanzapine, quetiapine, aripiprazole, risperidone, and lamotrigine. Some anticonvulsants and memantine show some use in the treatment and prophylaxis of bipolar disorder.

Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, life-threatening conditions with clinical symptoms of skin erosion and extensive epidermal detachment, usually caused by drug exposure over weeks to months. Although Stevens-Johnson syndrome is a rare disease, it is potentially fatal even among healthy patients. Among anticonvulsants, phenytoin, lamotrigine, and carbamazepine are most frequently associated with SJS/TEN. Very few cases suggest that clozapine, risperidone, ziprasidone, and aripiprazole can cause Stevens-Johnson syndrome. Meanwhile, valproic acid is considered low risk. However, the risk of valproic acid associated with SJS/TEN cannot be underestimated in current clinical practice.

This case report found that several mood stabilizer drugs had the side effects of Stevens-Johnson Syndrome, where clinical symptoms include blistering, swelling and pain in the skin. The patient is known to have been on medication using risperidone and valproic acid in the last three weeks.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Cindy Chias Arthy
AU  - Rini Adriany Lubis
PY  - 2024
DA  - 2024/12/20
TI  - Mood Stabilizer Induced Steven Johnson Syndrome
BT  - Proceedings of the 7th International Conference on Neuroscience, Neurology, and Psychiatry Universitas Sumatera Utara (ICONAP 2024)
PB  - Atlantis Press
SP  - 37
EP  - 41
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-616-1_6
DO  - 10.2991/978-94-6463-616-1_6
ID  - Arthy2024
ER  -