Proceedings of the 5th International Conference on Neuroscience, Neurology and Psychiatry (ICONAP 2022)

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Myasthenia Gravis with Mediastinal Tumors

Authors
Alfansuri Kadri1, *, Utami Tarigan1
1Department of Neurology, Faculty of Medicine, University of North Sumatera, Medan, Indonesia
*Corresponding author. Email: alfansurikadri@yahoo.com
Corresponding Author
Alfansuri Kadri
Available Online 31 March 2023.
DOI
10.2991/978-94-6463-120-3_22How to use a DOI?
Keywords
Myasthenia Gravis; Mediastinal Tumor; Paraneoplastic syndrome
Abstract

Introduction: Myasthenia Gravis (MG) is an autoimmune disease caused by antibodies targeting acetylcholine receptors to reduce the depolarization ability of extraocular, bulbar, and proximal muscles. Mediastinal tumors associated with MG are known as paraneoplastic syndromes and are primarily found in the anterior compartment, consisting of thymoma, lymphoma, and germ cell tumors.

Case Report: Two cases of MG with mediastinal tumors came for examination at H. Adam Malik General Hospital (RSUP HAM), Medan. Each of these cases has a different clinical presentation and symptoms. In the first case, MG with thymoma presented symptoms of ptosis, diplopia, dysphagia, dysphonia, and dropped head. The second case was MG with Primary Mediastinal Large B Cell Non-Hodgkin Lymphoma with symptoms of dysphonia and dysphagia. The patients were subjected to different treatments and experienced significant clinical improvement.

Discussion and Conclusion: The diagnosis of mediastinal tumors was established based on clinical symptoms, neurological examination, and investigations. The first case was managed using acetylcholinesterase inhibitors, steroids, non-steroidal immunosuppressants, and thymectomy, while the second utilized acetylcholinesterase inhibitors, steroid immunosuppressants, and radiotherapy.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 5th International Conference on Neuroscience, Neurology and Psychiatry (ICONAP 2022)
Series
Advances in Health Sciences Research
Publication Date
31 March 2023
ISBN
978-94-6463-120-3
ISSN
2468-5739
DOI
10.2991/978-94-6463-120-3_22How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Alfansuri Kadri
AU  - Utami Tarigan
PY  - 2023
DA  - 2023/03/31
TI  - Myasthenia Gravis with Mediastinal Tumors
BT  - Proceedings of the 5th International Conference on Neuroscience, Neurology and Psychiatry (ICONAP 2022)
PB  - Atlantis Press
SP  - 144
EP  - 152
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-120-3_22
DO  - 10.2991/978-94-6463-120-3_22
ID  - Kadri2023
ER  -