Prevalence of Squalene Epoxidase Mutation in Terbinafine Resistance: A Systematic Review

DOI

10.2991/978-94-6463-208-8_5How to use a DOI?

Keywords

dermatophytosis; terbinafine; resistance; squalene; mutation

Abstract

Dermatophytosis is a global burden of disease, as it affects around 20–25% of worldwide population. Many antifungal drugs have been developed to treat dermatophytosis that mainly inhibit the ergosterol biosynthesis. Terbinafine as the drug-of-choice has fungicidal effect by inhibiting ergosterol synthesis at the level of squalene epoxidation. Unfortunately, recently many countries reported the emerging terbinafine resistance. However, the exact mechanism of terbinafine resistance is still not clearly understood. Therefore, this paper aimed to provide a systematic literature review that describes the terbinafine resistance via squalene enzyme mutations. We conducted systematic searching to describe the prevalence of squalene enzyme mutation in terbinafine resistance. MEDLINE database was searched with keywords: dermatophytosis, terbinafine, resistance, squalene, mutation. According to our criteria and search protocol, six studies were included that performed squalene enzyme mutation analysis among terbinafine-resistant isolates. Data of those studies were collected to determine a cumulative prevalence of squalene enzyme mutation. According to our systematic review, we found that squalene mutation occurred in 80.39% of terbinafine resistant patients. The consistent finding of squalene enzyme mutation in terbinafine resistance may be seen to provide better strategy in dermatophytosis treatment. Further research may be developed to target another mechanism of anti-mycosis, as well as overcoming the drug resistance to benefit patients with dermatophytosis.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Fika Humaeda Assilmi
AU  - Cornelia Ghea Savitri
PY  - 2023
DA  - 2023/06/26
TI  - Prevalence of Squalene Epoxidase Mutation in Terbinafine Resistance: A Systematic Review
BT  - Proceedings of the International Conference of Medical and Life Science (ICoMELISA 2021)
PB  - Atlantis Press
SP  - 21
EP  - 26
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-208-8_5
DO  - 10.2991/978-94-6463-208-8_5
ID  - Assilmi2023
ER  -