Literature Review of Atherosclerosis Treatment with Hibiscus Sabdariffa as an Alternative for Statin Therapy
- DOI
- 10.2991/978-94-6463-208-8_8How to use a DOI?
- Keywords
- Atherosclerosis; Hibiscus sabdariffa; Statin
- Abstract
Coronary heart disease (CHD) ranks the second-highest cause of mortality after stroke, thereby emphasizing CHD as the most significant contributor to cardiovascular disease (CVD) mortality. Statin therapy serves as an efficacious treatment in regressing the number of CHD cases. However, current studies highlighted a prolonged side effect of statin therapy; thereby, a more effective, safe and alternative effort is required in addressing such notion. Hibiscus sabdariffa (HS) is currently an alternative herbal treatment to treat CHD due to atherosclerosis prevalence. Thus, this literature review examines HS potential as an alternative and less risky approach in statin therapy. In compiling this literature review, the PRISMA method was applied, cited through articles and journals sourced from 6 databases: PubMed, Google Scholar, NCBI, MDPI, ScienceDirect, and SpringerLink. Researches indicated that HS contained phytochemicals, depicted an active role in minimizing risk factors for atherosclerosis. Anthocyanins and polyphenols comprised the phytochemicals stored by HS. Anthocyanins worked as an inhibitor of Low-Density Lipoprotein (LDL) oxidation, acted as a potent antioxidant and a high blood pressure-lowering factor.
Meanwhile, polyphenol compounds played a role in overcoming hypercholesterolemia which generated a risk factor for atherosclerosis. These two compounds further proved that HS could offer an alternative treatment for CHD due to atherosclerosis prevalence. In sum, this literature review encouraged further researches highlighting the toxicity tests and the appropriate dose to observe HS potency while utilizing a broader sample of Hibiscus sabdariffa extract (HES) as an alternative for statin therapy.
- Copyright
- © 2023 The Author(s)
- Open Access
- Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Cite this article
TY - CONF AU - Balqis Faizah Azzahra AU - Umi Setyo Cahyanti AU - Rifqi Aulia Nurazizah AU - Rachmi Fauziah Rahayu AU - Yuyun Yueniwati PY - 2023 DA - 2023/06/26 TI - Literature Review of Atherosclerosis Treatment with Hibiscus Sabdariffa as an Alternative for Statin Therapy BT - Proceedings of the International Conference of Medical and Life Science (ICoMELISA 2021) PB - Atlantis Press SP - 44 EP - 51 SN - 2468-5739 UR - https://doi.org/10.2991/978-94-6463-208-8_8 DO - 10.2991/978-94-6463-208-8_8 ID - Azzahra2023 ER -