In Silico Study of Antigenicity and Immunogenicity of the D7 Protein from Salivary Glands of Aedes aegypti

Kartika Senjarini; Susmaya Atmandaru; Ari Satia Nugraha; Syubbanul Wathon; Rike Oktarianti

doi:10.2991/978-94-6463-062-6_60

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In Silico Study of Antigenicity and Immunogenicity of the D7 Protein from Salivary Glands of Aedes aegypti

Authors

Kartika Senjarini¹, Susmaya Atmandaru¹, Ari Satia Nugraha², Syubbanul Wathon¹, Rike Oktarianti¹^{, *}

¹Biology Department, Faculty of Mathematics and Natural Sciences, University of Jember, Jember, Indonesia

²Faculty of Pharmacy, University of Jember, Jember, Indonesia

^*Corresponding author. Email: rike.fmipa@unej.ac.id

Corresponding Author

Rike Oktarianti

Available Online 22 December 2022.

DOI: 10.2991/978-94-6463-062-6_60 How to use a DOI?
Keywords: DHF; Aedes aegypti; Salivary Gland; D7 protein; Vaccine
Abstract: The Aedes aegypti mosquito has been known as the primary vector in the transmission of Dengue Hemorrhagic Fever (DHF). D7 protein has been reported as a protein expressed in the salivary glands of mosquito vectors that can increase the transmission of the pathogen because of its ability to immunosuppress the host immune response (immunogenic). This study aimed to perform an in-silico analysis of the antigenicity and immunogenicity of D7 protein from the salivary glands of the Aedes aegypti vector. The results showed that the D7 Ae. aegypti (accession number: P18153 (UNIPROT)) could be recognized as an antigenic and immunogenic protein by finding its predicted protein epitopes on B cell as well as T cell. The YYKCLVESS peptide was identified as a suitable candidate as a linear B cell epitope. The peptides KGLYEKLGKDI and KNQAYSKPAVMEIDGKQCPQ were identified as epitopes of conformational B cells. The LYDPVAQKF peptide has a high affinity; thus, it was identified as a T cell potential epitope. The identified epitope could be further evaluated at in vivo study to be developed as a potential transmission-blocking vaccine candidate for DHF.
Copyright: © 2023 The Author(s)
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)
Series: Advances in Biological Sciences Research
Publication Date: 22 December 2022
ISBN: 978-94-6463-062-6
ISSN: 2468-5747
DOI: 10.2991/978-94-6463-062-6_60 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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ris enw bib

TY  - CONF
AU  - Kartika Senjarini
AU  - Susmaya Atmandaru
AU  - Ari Satia Nugraha
AU  - Syubbanul Wathon
AU  - Rike Oktarianti
PY  - 2022
DA  - 2022/12/22
TI  - In Silico Study of Antigenicity and Immunogenicity of the D7 Protein from Salivary Glands of Aedes aegypti
BT  - Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)
PB  - Atlantis Press
SP  - 588
EP  - 595
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-062-6_60
DO  - 10.2991/978-94-6463-062-6_60
ID  - Senjarini2022
ER  -

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