Effects of EGCG on Learning and Memory Abilities in mice with Alzeimer's Disease

DOI

10.2991/icmmct-17.2017.248How to use a DOI?

Keywords

EGCG, Alzheimer's disease, animal model, learning and memory

Abstract

Objective: To make a study of the effects of EGCG on learning and memory abilities in mice with Alzeimer's disease. Methods: The mice were divided into normal control group, model control group, brain repair group, low EGCG dose group, middle EGCG dose group and high EGCG dose group. We use the evaluation method of Morris water to study the learning and memory acquisition and the SOD activity and MDA content. Results: Compared with the model group, the incubation period of EGCG high dose group mice was significantly shorten; quadrant dwell time of high dose group and middle dose group were prolonged; the activity of SOD increased obviously in high dose of EGCG in serum of mice and the content of MDA in the high dose group in mice serum decreased obviously. Conclusion: EGCG can obviously prevent and improve the learning and memory dysfunction in mice.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Weiya Lang
AU  - Zhongjin Li
AU  - Lihui Sun
AU  - DanYang Liu
AU  - Haiyan Zhang
PY  - 2017/04
DA  - 2017/04
TI  - Effects of EGCG on Learning and Memory Abilities in mice with Alzeimer's Disease
BT  - Proceedings of the 2017 5th International Conference on Machinery, Materials and Computing Technology (ICMMCT 2017)
PB  - Atlantis Press
SP  - 1273
EP  - 1278
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmmct-17.2017.248
DO  - 10.2991/icmmct-17.2017.248
ID  - Lang2017/04
ER  -