Synthesis of 5-Substituted Indole-2,3-dione

DOI

10.2991/icmmct-16.2016.152How to use a DOI?

Keywords

4-Substituted isonitroacetanilines, 5-Substituted indol-2,3-dione,Synthesis

Abstract

4-Substituted isonitroacetanilines 2 were prepared by the reaction of 4-substituted anilines 3 with chloral hydrate and hydroxylamine hydrochloride. 5-Substituted indol-2,3-dione 1 were prepared by the cyclization of 2 in the presence of concentrated sulfuric acid. 5-Substituted indol-2,3-dione 1 is an important intermediate in many biologically active compounds. The structure was confirmed by mass spectra (MS). Furthermore, the synthetic method was optimized. The total yield of the two steps was 51-68%(calculated from 4-substituted anilines).

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Dandan Zhao
AU  - Ping Wang
AU  - Tongsheng Xu
AU  - JieLian Wu
AU  - Jiajia Wang
AU  - Shan Xu
PY  - 2016/03
DA  - 2016/03
TI  - Synthesis of 5-Substituted Indole-2,3-dione
BT  - Proceedings of the 2016 4th International Conference on Machinery, Materials and Computing Technology
PB  - Atlantis Press
SP  - 776
EP  - 779
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmmct-16.2016.152
DO  - 10.2991/icmmct-16.2016.152
ID  - Zhao2016/03
ER  -