Study on Osteopontin and Its Clinical Application to Ovarian Cancer

DOI

10.2991/icmmcce-15.2015.380How to use a DOI?

Keywords

Osteopontin (OPN), Ovarian Cancer, Clinical Application

Abstract

Osteopontin (OPN) is a kind of phosphorylated acidic glycoprotein, human beings' osteoclasts, macrophages, T cells, and vascular smooth muscle cells can secrete OPN, the gene is located on chromosome 4q13. OPN has a function of adhesion to protein, which can be combined with CD44, integrin v 3 and v 5, OPN is also involved in bone remodeling, the formation of new blood vessel and the reflection of inflammation. OPN can play the synergistic function in tumor metastasis. In this paper, it takes the introduction of biological function of OPN. As for the aspect of early diagnosis of ovarian cancer and prognosis monitoring, it can be used as the supplement of CA125 and markers of other cytokines.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Lihong Bao
PY  - 2015/12
DA  - 2015/12
TI  - Study on Osteopontin and Its Clinical Application to Ovarian Cancer
BT  - Proceedings of the 4th International Conference on Mechatronics, Materials, Chemistry and Computer Engineering 2015
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/icmmcce-15.2015.380
DO  - 10.2991/icmmcce-15.2015.380
ID  - Bao2015/12
ER  -