Correlation of Alzheimer's Disease with Wnt Signaling Pathway and Neural Stem Cells

DOI

10.2991/icmmcce-15.2015.22How to use a DOI?

Keywords

Alzheimer's Disease, Wnt Signaling Pathway, Neural Stem Cells.

Abstract

Recent studies have shown that Wnt signaling molecules and the occurrence and development of Alzheimer's disease are closely related. Wnt protein secretion by autocrine or located next to the cell membrane receptor binding, activation of intracellular signaling pathways to regulate expression of target genes of cell proliferation during embryonic development, differentiation, migration, polarity and apoptosis has played an important role. The pathological mechanism of Alzheimer's disease involves inherited, environmental and immunological factors. Strong evidence exists that Wnt signaling pathway is closely related to the pathological process of Alzheimer's disease. There is also evidence that Wnt signaling pathway plays a crucial effect on the proliferation of neural stem cells. To review the relationship between pathological process of Alzheimer's disease and Wnt signaling pathway and effects of Wnt signaling on proliferation and differentiation of neural stem cells, providing theoretical evidence for treatment of Alzheimer's disease.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Hongbo Yao
AU  - Lihui Sun
AU  - Jie Lian
AU  - Meng Zhang
AU  - Danyang Liu
PY  - 2015/12
DA  - 2015/12
TI  - Correlation of Alzheimer's Disease with Wnt Signaling Pathway and Neural Stem Cells
BT  - Proceedings of the 4th International Conference on Mechatronics, Materials, Chemistry and Computer Engineering 2015
PB  - Atlantis Press
SP  - 119
EP  - 122
SN  - 2352-538X
UR  - https://doi.org/10.2991/icmmcce-15.2015.22
DO  - 10.2991/icmmcce-15.2015.22
ID  - Yao2015/12
ER  -