Chronic intermittent hypoxia training on rat myocardial mitochondria ATPase impact study Opportunities

DOI

10.2991/icmmbe-16.2016.138How to use a DOI?

Keywords

Hypoxic training; Mitochondria; Cardiac muscle; Na+, K+-ATPase; Ca2+, magnesium 2 + ATPase

Abstract

Objective: To study the chronic intermittent hypoxia training on rat myocardial line grain of ATP content and Na+, K+ ATPase and the influence of Ca2+, magnesium 2+ATPase. Methods: 32 male Wistar rats as the research object, according to the low oxygen training program can be divided into intermittent group, acute group and the control group, among which chronic intermittent hypoxia training, intermittent simulated altitude 3 km, 2 w, then simulated altitude training 5 km, 2 w training, daily training 4 h, finally simulated altitude 8 km, placed 4 h. Acute group immediately under simulated conditions of 8 km altitude 4 h; The control group are not hypoxic training. After the expiry of the low oxygen, beheaded executed after, separation of myocardial mitochondria, determination of ATP enzyme activity. Results: (1) atpase chronic group content (9.04±4.71 mg/100 mg of BW, (4.96-1.17) in the acute group mg/100mg of BW and the control group (4.38±0.95 mg/100 mg of BW were significantly higher, significant difference, statistically significant (P<0.05). (2) chronic group of Na+, K+ ATPase activity (2.55±1.41) mu mol, pro-1mg/h, (2.66±1.07) in the acute group mu mol, pro - 1 mg/h and the control group (3.08±1.37) mu mol, pro-1mg/h had no significant difference.(3) chronic group of Ca2+, magnesium 2 + ATPase activity (1.17±0.34) mu mol, pro-1mg/h, the control group (1.28±0.42) mu mol, pro-1mg/h no significant difference, but the acute group (0.58±0.14) mu mol, mg/h significantly higher pro -1, the difference has statistical significance (P<0.05). Conclusion: chronic intermittent hypoxia training to ensure the Ca2+, magnesium 2+ ATPase activity has a positive meaning, at the same time can significantly increase the content of ATPase, help to improve myocardial motion function, adapt the rat hypoxic environment.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Congjun Yang
PY  - 2016/09
DA  - 2016/09
TI  - Chronic intermittent hypoxia training on rat myocardial mitochondria ATPase impact study Opportunities
BT  - Proceedings of the6th International Conference on Mechatronics, Materials, Biotechnology and Environment (ICMMBE 2016)
PB  - Atlantis Press
SP  - 731
EP  - 734
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmmbe-16.2016.138
DO  - 10.2991/icmmbe-16.2016.138
ID  - Yang2016/09
ER  -