Proceedings of the 3rd International Conference on Mechanical Engineering and Intelligent Systems (ICMEIS 2015)

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PGRN negative regulates apoptosis through TNFR signaling pathway in chondrogenesis

Authors
Zhangyuan Xiong, Rong Jiang, Meilin LI, Feng-Jin Guo
Corresponding Author
Zhangyuan Xiong
Available Online August 2015.
DOI
10.2991/icmeis-15.2015.3How to use a DOI?
Keywords
PGRN; Endoplasmic reticulum stress; Apoptosis; UPR; TNF receptor.
Abstract

BMP2 is known to activate ER stress-associated molecules,including XBP1S and ATF6.PGRN (Progranulin) was reported to be a stress-response factor in response to hypoxia and acidosis. Here we present evidences demonstrating that PGRN is also an ER stress responsive factor.PGRN expression was induced and its activation of Erk1/2 and Akt signaling enhanced in BMP2-induced chondrocyte differentiation.Besides,overexpression PGRN can inhibit,whereas knockdown PGRN by an siRNA-silencing approach increased,ER stress-mediated apoptosis in chondrogenesis induced by BMP2.Mechanistic studies indicated that PGRN/TNFR2 was critical for PGRN mediated regulation of ER stress response; the association between PGRN and TNFR2 was markedly enhanced following ER stress;More importantly,PGRN protection of ER stress induced apoptosis was abolished when TNFR2 signaling was blocked.Collectively,PGRN plays an important role in ER stress and regulates ER stress response through interacting with TNFR2.This study provides new insight into PGRN regulation of stress response and may also present PGRN as a potential molecular target for treating stress-associated disorders.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 3rd International Conference on Mechanical Engineering and Intelligent Systems (ICMEIS 2015)
Series
Advances in Engineering Research
Publication Date
August 2015
ISBN
978-94-62520-98-1
ISSN
2352-5401
DOI
10.2991/icmeis-15.2015.3How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Zhangyuan Xiong
AU  - Rong Jiang
AU  - Meilin LI
AU  - Feng-Jin Guo
PY  - 2015/08
DA  - 2015/08
TI  - PGRN negative regulates apoptosis through TNFR signaling pathway in chondrogenesis
BT  - Proceedings of the 3rd International Conference on Mechanical Engineering and Intelligent Systems (ICMEIS 2015)
PB  - Atlantis Press
SP  - 12
EP  - 16
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmeis-15.2015.3
DO  - 10.2991/icmeis-15.2015.3
ID  - Xiong2015/08
ER  -