Influence of Polydatin on the Blood Lipid of Rat with Hyperlipemia

DOI

10.2991/icmcm-16.2016.49How to use a DOI?

Keywords

Polydatin; Atherosclerosis; Hyperlipemia.

Abstract

Objective: Discuss the regulating effect of polydatin on the blood lipid of rat with with hyperlipemia. Method: rats were fed with the high-fat feeding method; the early atherosclerosis (AS) model of rat was established; after successful modeling, rats were given by gavage high-dose, medium-dose and low-dose of polydatin (160,80,40mg-kg-1-d-1); 8 weeks later, rats' TC, TG, HDL-C, LDL-C, TNF- , NO and iNOS were measured. Result: the group with high-dose, medium-dose and low-dose of polydatin can significantly lower the serum TC, TG, LDL-C, TNF- , NO level and iNOS activity and enhance the HDL-C. The difference is of statistical significance (P <0.05). Conclusion: Polydatin can regulate blood lipids and alleviate the occurrence and development of atherosclerosis. This may be related to its regulation of the formation and expression of NO and nitric oxide synthase.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Enhong Ouyang
AU  - Junhua Liu
AU  - Hailiang Wei
AU  - Gengxi Li
PY  - 2016/12
DA  - 2016/12
TI  - Influence of Polydatin on the Blood Lipid of Rat with Hyperlipemia
BT  - Proceedings of the 2016 7th International Conference on Mechatronics, Control and Materials (ICMCM 2016)
PB  - Atlantis Press
SP  - 240
EP  - 243
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmcm-16.2016.49
DO  - 10.2991/icmcm-16.2016.49
ID  - Ouyang2016/12
ER  -