Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials

Synthesis of Histone Deacetylases Inhibitor and Activity in Vitro

Authors
Baoping Kuang, Hui Zhang, Zhihang Shang
Corresponding Author
Baoping Kuang
Available Online July 2015.
DOI
10.2991/icimm-15.2015.103How to use a DOI?
Keywords
Vorinostat; Histone Deacetylases Inhibitor; Multi-Drug Resistance
Abstract

Multi-drug resistance (MDR) is an important element which leads to ineffectiveness of chemotherapeutics. The discovery of histone acetylase’s unusual activities in tumor cells provides a new area for the cure of cancer. And histone deacetylases inhibitor (HDACi) is used as a new agent in clinical therapy. New histone deacetylases inhibitors have been synthesized. All the products have been characterized by 1H-NMR and MS. The activities in vitro effects on the title compounds were examined. From the biological activity results, we found that three compounds showed good inhibitory potency against HDACs and anti-proliferate activities to inhibit human colonic cancer cells growth.Introduction.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials
Series
Advances in Engineering Research
Publication Date
July 2015
ISBN
978-94-62520-88-2
ISSN
2352-5401
DOI
10.2991/icimm-15.2015.103How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Baoping Kuang
AU  - Hui Zhang
AU  - Zhihang Shang
PY  - 2015/07
DA  - 2015/07
TI  - Synthesis of Histone Deacetylases Inhibitor and Activity in Vitro
BT  - Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials
PB  - Atlantis Press
SP  - 547
EP  - 552
SN  - 2352-5401
UR  - https://doi.org/10.2991/icimm-15.2015.103
DO  - 10.2991/icimm-15.2015.103
ID  - Kuang2015/07
ER  -