Synthesis of Histone Deacetylases Inhibitor and Activity in Vitro

DOI

10.2991/icimm-15.2015.103How to use a DOI?

Keywords

Vorinostat; Histone Deacetylases Inhibitor; Multi-Drug Resistance

Abstract

Multi-drug resistance (MDR) is an important element which leads to ineffectiveness of chemotherapeutics. The discovery of histone acetylase’s unusual activities in tumor cells provides a new area for the cure of cancer. And histone deacetylases inhibitor (HDACi) is used as a new agent in clinical therapy. New histone deacetylases inhibitors have been synthesized. All the products have been characterized by 1H-NMR and MS. The activities in vitro effects on the title compounds were examined. From the biological activity results, we found that three compounds showed good inhibitory potency against HDACs and anti-proliferate activities to inhibit human colonic cancer cells growth.Introduction.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Baoping Kuang
AU  - Hui Zhang
AU  - Zhihang Shang
PY  - 2015/07
DA  - 2015/07
TI  - Synthesis of Histone Deacetylases Inhibitor and Activity in Vitro
BT  - Proceedings of the 5th International Conference on Information Engineering for Mechanics and Materials
PB  - Atlantis Press
SP  - 547
EP  - 552
SN  - 2352-5401
UR  - https://doi.org/10.2991/icimm-15.2015.103
DO  - 10.2991/icimm-15.2015.103
ID  - Kuang2015/07
ER  -