The Research of Neutrophil Extracellular Traps in the Blood of Women with Malignization of Cervical Epithelium

DOI

10.2991/ichw-19.2019.33How to use a DOI?

Keywords

cervical cancer, neutrophil extracellular traps, cancerogenesis

Abstract

Neutrophil extracellular traps (NETs) are destroyed neutrophils combined with DNA, proteins, and enzymes; they are the destruction mechanisms of a cell attacked by pathogens. Currently its pathophysiological contribution to the neoplastic process remains controversial. The aim is to determine the number of NETs in the blood of women with cervical cells malignization. The research covered 21 cases - 7 women with cervical premalignancies (I group) and 14 women with cervical cancer of stages 0-III (II group). The average age of patients was 38±8.26. The control group was formed of volunteers without cervical pathologies (n=10). Blood serum was used as the material for the research. Neutrophils, monocytes, and NETs were counted in Feulgen stained blood smears by the optical microscope. The count was performed per 100 cells. In addition, we performed retrospective analysis of some blood parameters of the examined individuals. NETs were not found in the blood of healthy women and women with premalignancies. NETs were observed in the blood of 70% of patients with cervical cancer. The maximum number was found in the blood of patients with stage IIb cancer. Leukocytosis was registered in the blood of the patients diagnosed with cervical cancer due to neutrophilia and lymphopenia. The discovered changes increased as the neoplastic process aggravated. The results of the study and literature data point to the existing changes in blood neutrophils of the patients with cervical cancer and NETs participation in cervical carcinogenesis which requires further research.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - E. Kayukova
AU  - L. Sholokhov
AU  - T. Belokrinitskaya
PY  - 2019/10
DA  - 2019/10
TI  - The Research of Neutrophil Extracellular Traps in the Blood of Women with  Malignization of Cervical Epithelium
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 137
EP  - 141
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.33
DO  - 10.2991/ichw-19.2019.33
ID  - Kayukova2019/10
ER  -