Mutation Frequency in BRCA1 And BRCA2 Genes Among Women with Breast Cancer in Kabardino-Balkaria

DOI

10.2991/ichw-19.2019.19How to use a DOI?

Keywords

breast cancer (BC) gene BRCA1, gene BRCA2, heriditary susceptibility, Kabardino-Balkaria

Abstract

The study was conducted within the individual genotyping of healthy and sick women in the Kabardino-Balkarian Republic to determine the risk-prone groups with increased susceptibility to hereditary form of breast cancer development. Blood samplings were collected and total DNA was taken from 300 people (control and experimental groups). The frequency of 5382insC, 4154delA, 185delAG BRCA1 mutations and 6174delT mutations of the BRCA2 gene among women with breast cancer was studied. The data obtained along with the survey suggest the hereditary or sporadic nature of the disease. A comparative analysis of the frequencies of genes alleles towards susceptibility to the hereditary form of this disease will provide an opportunity to discover the genetic reasons for an increase in cancer and to identify the groups of the greatest risk.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - M. Bittueva
AU  - P. Dzhambetova
AU  - D. Hashhozheva
AU  - Z. Bogotova
AU  - T. Handohov
PY  - 2019/10
DA  - 2019/10
TI  - Mutation Frequency in BRCA1 And BRCA2 Genes Among Women with Breast Cancer in Kabardino-Balkaria
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 77
EP  - 80
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.19
DO  - 10.2991/ichw-19.2019.19
ID  - Bittueva2019/10
ER  -