Is Genome Instability a Significant Cause of Aging? A Review

DOI

10.2991/assehr.k.220504.260How to use a DOI?

Keywords

“aging”; “genome instability”; “mitochondrial DNA”; “telomeres”

Abstract

What is the main cause of aging has been discussed over last decades. Accumulating evidences has indicated that genome instability including mitochondrial DNA in somatic cell played an important role in human aging process. Various sources of damage such as reactive oxygen species and UV radiation can lead to the decrease of DNA robustness. In addition, the erroneous replication and failure in DNA maintenance system is also able to casus mutations and epimutations. In this review we will first summarize the relation between the accumulation of DNA damage and longevity. Then we will review the contribution made by mitochondrial free radical to the aging process. Finally, we will briefly discuss whether the telomere is an eligible biomarker of life span.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license.

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TY  - CONF
AU  - Yunxie Xing
PY  - 2022
DA  - 2022/06/01
TI  - Is Genome Instability a Significant Cause of Aging? A Review
BT  - Proceedings of the 2022 8th International Conference on Humanities and Social Science Research (ICHSSR 2022)
PB  - Atlantis Press
SP  - 1432
EP  - 1445
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220504.260
DO  - 10.2991/assehr.k.220504.260
ID  - Xing2022
ER  -