Investigation of Anti-dengue Virus (DeNV) Molecules from a Marine-Derived Bacterium
- DOI
- 10.2991/978-94-6463-112-8_14How to use a DOI?
- Keywords
- dengue; virus; bioactive compound; marine bacteria
- Abstract
Dengue is a viral infection spread by mosquitos that occur in tropical and subtropical areas in the world. Presently, there is no directly acting drug against Dengue Virus (DeNV) for clinical use. Therefore, developing new medicines is required to control the severity of outbreaks. In this proceeding, several bioactive compounds 1–3 isolated from marine-derived bacterium will be reported. Compounds 1–3 were analyzed by several spectrophotometers and concluded as a cyclo(L-Leu-L-pro) (1), nocardamine (2) and cycloheximide (3). Compound 1 showed anti-DeNV activity with IC50 0.38 mg/ml, CC50 6.03 mg/ml, and SI 15.75. Compound 2 exhibited activity against DeNV with IC50 > 10 mg/ml, CC50 7.96 mg/ml, and SI < 0.80. Compound 3 elicited an excellent activity with IC50 0.02 mg/ml, CC50 0.28 mg/ml, and SI 13.70.
- Copyright
- © 2023 The Author(s)
- Open Access
- Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Cite this article
TY - CONF AU - Peni Ahmadi AU - Takahiro Haruyama AU - Nobuyuki Kobayashi AU - Junichi Tanaka PY - 2023 DA - 2023/03/01 TI - Investigation of Anti-dengue Virus (DeNV) Molecules from a Marine-Derived Bacterium BT - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022) PB - Atlantis Press SP - 136 EP - 148 SN - 2468-5739 UR - https://doi.org/10.2991/978-94-6463-112-8_14 DO - 10.2991/978-94-6463-112-8_14 ID - Ahmadi2023 ER -