Standardization of Spray-Dried Powder of Morinda citrifolia Fruit Extract

DOI

10.2991/978-94-6463-112-8_27How to use a DOI?

Keywords

Encapsulation; Mengkudu fruits extract; Spray-dried powder; Standardized extract

Abstract

Morinda citrifolia L. (Mengkudu) has been widely used in herbal medicine to prevent and treat various diseases. In the Indonesian Original Herbal Medicine Formularies list, Mengkudu is an ingredient for treating hypertension and dyslipidemia. The various efficacy activities are due to the great active compound content in the extract. All bioactive compounds in herbal extracts are highly susceptible to degradation by environmental and chemical factors that will affect the activation of compounds in the extract. The encapsulation method is a prospective strategy for maintaining the stability of the active compounds in herbal extracts. Spray drying encapsulation technology is one of the most efficient and widely used methods for encapsulating bioactive compounds from natural extract. The encapsulation of Mengkudu fruit extract can provide protection over the bioactive compounds in the extract and can mask the unpleasant taste. In the current study, Mengkudu fruit was extracted with 70% ethanol then encapsulated using spray drying using 50% (w/w) maltodextrin as encapsulate. This study aims to standardize spray-dried Mengkudu fruit extract powder. A variety of physicochemical parameters analysis e.g., total ash, water-soluble ash, and acid insoluble ash, moisture content, and loss on drying, were analyzed as per the standard methods including microbial contamination and heavy metal contaminant was measured by Inductively coupled plasma - optical emission spectrometry (ICP-OES). The fingerprinting of ethanolic extract and spray-dried powder of Mengkudu was also carried out using the CAMAG-HPTLC system to determine scopoletin as a marker compound. The encapsulation yield of the spray drying process was also measured. This process was carried out on a pilot-scale spray drying using maltodextrin as a coating material. The water content, total ash, acid insoluble ash, water-soluble ash, and encapsulation yield were 3.31, 0.6, 0.07, 0.53, and 60.53, respectively. The results of the ICP-OES analysis showed that no heavy metals were detected in the powder, while the pathogenic microbial contamination test also showed negative results. HPTLC analysis revealed that the scopoletin content was 1.43 mg/g of spray-dried powder. In conclusion, the results obtained from this study can be used to standardize spray-dried powder of noni fruit extract in the manufacture of standardized herbal medicine.

Copyright

© 2023 The Author(s)

Open Access

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TY  - CONF
AU  - Rizna T. Dewi
AU  - Sukirno Sukirno
AU  - Rifqah Azzahra
PY  - 2023
DA  - 2023/03/01
TI  - Standardization of Spray-Dried Powder of Morinda citrifolia Fruit Extract
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 278
EP  - 287
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_27
DO  - 10.2991/978-94-6463-112-8_27
ID  - Dewi2023
ER  -