Convalescent Plasma Effect to Neutralization Antibody and Inflammation Parameter Level in Moderate COVID-19 Patients

DOI

10.2991/978-94-6463-112-8_68How to use a DOI?

Keywords

COVID-19; convalescent plasma; neutralization antibody; inflammatory parameters; Interleukin-6; C-Reactive Protein

Abstract

The pandemic of COVID-19 continues with new variants. More than 401 million people in the world infected by COVID-19 and approximately 5.7 million people lost their lives. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has respiratory system as a target. This virus uses a receptor binding domain of SARS-CoV-2 Spike (sRBD) protein to bind ACE-2 receptor and enter human respiratory cells. The antibody to sRBD protein will block the virus. Convalescent plasma from recovered COVID-19 patient contains neutralization antibody which can neutralize sRBD and eliminate the virus. Therefore, this study aims to assess the therapeutic effect of convalescent plasma to neutralization antibody and inflammatory parameter level in moderate COVID-19 patients. This is a one-group pretest-posttest study of nine moderate COVID-19 patients admitted in Unggul Karsa Medika Hospital, Bandung, Indonesia. The study was done from August 1, 2021 to January 1, 2022. The level of neutralization antibody and inflammatory parameter were assessed before and after convalescent plasma therapy in moderate COVID-19 patient. Data analysis performed by SPSS program with p < 0.05 and dependent t-test. Our study shows that convalescent plasma therapy can influence the increase of neutralization antibody (142. 5 AU/mL vs 13.432 AU/mL, p value = 0.011) and the decrease of Interleukin-6 (IL-6) (41.61 pg/mL vs 14.5 pg/mL, p value = 0.008) and C-reactive protein (CRP) level (84.2 mg/L vs 17.4 mg/L, p-value = 0.018) in moderate COVID-19 patient. The patients were also getting better clinically, with the use of oxygen decreasing gradually from non-rebreathing masks to nasal cannula and from nasal cannula to room air after given convalescent plasma therapy. Therefore, we conclude that convalescent plasma therapy has a positive role in increasing neutralization antibody and decreasing inflammatory parameters which are IL-6 and CRP, thus had potential usefulness in therapy for moderate COVID-19 patients.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Theresia M. Rahardjo
AU  - Hendra Subroto
AU  - Christian Adiutama
AU  - Mochamad Fachrureza
AU  - Anita Ramlie
AU  - Aloysius Suryawan
AU  - Diana K. Jasaputra
AU  - Jeffrey C. Mahardhika
PY  - 2023
DA  - 2023/03/01
TI  - Convalescent Plasma Effect to Neutralization Antibody and Inflammation Parameter Level in Moderate COVID-19 Patients
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 755
EP  - 763
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_68
DO  - 10.2991/978-94-6463-112-8_68
ID  - Rahardjo2023
ER  -