Functional and Behavioral Adaptation After Intermittent Hypobaric Hypoxia Induction in Sprague-Dawley Rats Brain

DOI

10.2991/ichlas-17.2017.38How to use a DOI?

Keywords

Attitude; contraceptions; Family Planning; Knowledge; IUD

Abstract

Intermittent hypobaric hypoxia (IHH) is believed to have neuroprotective effect. IHH induces changes in gene expression and intracellular signaling pathways that lead to the emergence of intracellular adaptation through HIF-1 alpha gene activity. IHH induction decreased brain cortical tissue damage, and increased microvascular density. Further study is needed to understand physiological and behavioral response after IHH induction. The aim of this study is to investigate the effect of IHH on neuronal function in conducting neurotransmitters. A total of 25 Sprague-Dawley rats were divided into 5 groups: 1 group as control and 4 groups exposed to hypobaric hypoxia (HH). 1 group were exposed to single HH, and 3 groups exposed to HH intermittently (1 week interval) in Indonesian Air Force Institute of Aviation Medicine using hypobaric chamber. After the induction, the rat brain was taken for immunochemistry analysis. The level of GABAA receptor and glutamate receptor (NMDAR) decreased significantly in single HH group, but raised significantly after intermittent induction compare to control group (p<0.05). IHH induction shows adaptation respons in neurotransmitter conduction in Sprague-Dawley rats brain.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Fanny S. Farhan
AU  - Mohamad Sadikin
AU  - Sri WA. Jusman
AU  - Wawan Mulyawan
PY  - 2017/12
DA  - 2017/12
TI  - Functional and Behavioral Adaptation After Intermittent Hypobaric Hypoxia Induction in Sprague-Dawley Rats Brain
BT  - Proceedings of the 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017)
PB  - Atlantis Press
SP  - 46
EP  - 50
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichlas-17.2017.38
DO  - 10.2991/ichlas-17.2017.38
ID  - Farhan2017/12
ER  -