A New Approach to the Treatment of Oral Cancer With Cempedak Sea Cucumber (Bohadsch Marmorata) of Mentawai Islands

DOI

10.2991/ahsr.k.220303.030How to use a DOI?

Keywords

Cempedak sea cucumber (Bohadschia marmorata) etyl acetate fractions; anticancer; Supri’s Clone 1 (SP-CI)

Abstract

Oral Squamous cell carcinoma cases tend to increase and account for more than 90% of all oral cancers. Among the standard treatments are surgery, radiotherapy, chemotherapy or combination, however most patients with oral carcinoma, especially tongue carcinoma, are admitted to the hospital at an advanced stage. During the last few decades, there have been no effective systemic therapy for patients with advanced tongue carcinoma, thus the prognosis for patients with advanced tongue carcinoma is still very limited. One of the treatments being developed is the search for natural or herbal ingredients. Sea cucumbers have important bioactive compounds and are believed to have strong anticancer activity. The bioactive compounds that act as anti-cancer in sea cucumbers are triterpene glycosides. The Bohadschia marmorata or brown sea cucumber (Indonesian: Teripang Cempedak) is one of the dominant species in the West Sumatran. This study aims to determine the anticancer activity of the extract and fractionation of cempedak sea cucumber (Bohadschia marmorata) of the Mentawai islands, West Sumatra. This research is a laboratory experimental study to identify the anticancer activity of the extract and fractionation of cempedak sea cucumber (Bohadschia marmorata) using the MTT cytotoxic assay test to measure IC50 against Supri’s-Clone 1 (SP-C1) tongue cancer cells derived from the results of lymphodenopathy cloning of patients with carcinomacell squamous tongue. The bioactive compounds in the cempedak sea cucumber fractions etyl acetate (Bohadschia marmorata) indeed have strong anti-cancer activity against SP-C1, IC₅₀ value was 18,833, means that the fractions etyl acetate of cempedak sea cucumber has a strong cytotoxic effect (18,833 < IC₅₀ < 100) against SP-C1 cancer cells. Cempedak sea cucumber etyl acetate fractions indeed has a strong cytotoxic effect on SP-C1 cancer cells, therefore the cempedak sea cucumber etyl acetate fractions has the potential to be developed as a source of new cancer drugs.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

Download article (PDF)

TY  - CONF
AU  - Utmi Arma
AU  - Sisca Yudistira
PY  - 2022
DA  - 2022/03/08
TI  - A New Approach to the Treatment of Oral Cancer With Cempedak Sea Cucumber (Bohadsch Marmorata) of Mentawai Islands
BT  - Proceedings of 1st International Conference on Health Sciences and Biotechnology (ICHB 2021)
PB  - Atlantis Press
SP  - 148
EP  - 151
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220303.030
DO  - 10.2991/ahsr.k.220303.030
ID  - Arma2022
ER  -