Ki-67 Expression to Differ Histopathological Variant Basal Cell Carcinoma

DOI

10.2991/ahsr.k.220303.018How to use a DOI?

Keywords

Varian histopathology of BCC; aggressive BCC; non aggressive BCC; Ki-67; proliferation index

Abstract

Basal cell carcinoma (BCC) is a common skin malignancy in humans. Cancer rarely metastasizes but it is locally destructive and recurrent, particularly an aggressive variant. Various risk factors are associated with the behavior of BCC, leading to DNA damage resulting in an increase in cell proliferation. The proliferation is a key tumor progression as assessed by Ki-67 expression. Previous studies have shown there is a relationship between the proliferation marker Ki-67 and histopathological variants BCC, but it is not clearly understood. Objectives: This study assesses Ki-67 expression in histopathology variants BCC. Methods: The sample using 40 cases consisted of 20 samples of aggressive BCC and 20 samples of non-aggressive BCC. Each sample was stained by immunohistochemical and assessed by Ki-67 proliferation index. Result: This study shows that 90% of aggressive BCC have a positive 2 proliferation index of Ki-67 and 75 % non-aggressive BCC with positive 1 Ki-67 expression. The Ki-67 expression has a significant correlation to histopathological variants of BCC, in which an aggressive variant has higher index proliferation than a non-aggressive variant. Conclusion: Expression of Ki-67 plays a role in different aggressive from non-aggressive BCC.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Meta Zulyati Oktora
AU  - Silvi Yelitha
AU  - Pamelia Mayorita
AU  - Hera Novianti
PY  - 2022
DA  - 2022/03/08
TI  - Ki-67 Expression to Differ Histopathological Variant Basal Cell Carcinoma
BT  - Proceedings of 1st International Conference on Health Sciences and Biotechnology (ICHB 2021)
PB  - Atlantis Press
SP  - 89
EP  - 94
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220303.018
DO  - 10.2991/ahsr.k.220303.018
ID  - Oktora2022
ER  -