The Effect of Apple Guava Juice on Macrophages Level in Mice Wound on Fifth Day

DOI

10.2991/ahsr.k.220303.003How to use a DOI?

Keywords

Apple Guava; Macrophage; Wound Healing; Inflammation; Immunity

Abstract

The body’s immune system can affect the wound healing process. In improving the body’s immune system, anti- oxidants as pro-anti-inflammatory is important. Delay wound healing may be due to the length of the inflammatory phase. Guava juice contains a lot of chemical compositions such as lycopene, ascorbic acid, minerals, vitamins, fats, and amino acids that the body needs as a source of energy and anti-oxidants to accelerate wound healing. The sample is mice injured, selected to obtain good samples. One day after being injured, the mice were treated with guava juice with doses ranging from 1 ml to 5 ml per day for 3 consecutive days. On the 5th day, mice were taken randomly in each group with a proportion of 1 mice per group to take the wound tissue for histology with hematoksilin and eosin staining. The preparations were viewed microscopically with a magnification of 400 times. The results of the study that group A, macrophages and monocytes was viewed rare. In group B, the number of monocytes that were expected to develop into macrophages was very good viewed but the number of macrophages was still less compared to groups C and D, which number and highlighted of monocytes is viewed clearly. In group E, monocytes have been replaced by fibroblasts and collagen threads. The conclusion, guava juice can accelerate the formation of macrophages from monocytes as phagocytic cells in the process of wound healing. The effective dose for wound healing in mice is 5 ml per day.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

Download article (PDF)

TY  - CONF
AU  - Agustika Antoni
AU  - Nicen Suherlin
AU  - Sri Oktarina
PY  - 2022
DA  - 2022/03/08
TI  - The Effect of Apple Guava Juice on Macrophages Level in Mice Wound on Fifth Day
BT  - Proceedings of 1st International Conference on Health Sciences and Biotechnology (ICHB 2021)
PB  - Atlantis Press
SP  - 12
EP  - 18
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220303.003
DO  - 10.2991/ahsr.k.220303.003
ID  - Antoni2022
ER  -